www.chargersfootballauthentics.com , they're not even sure which holes to fill first.Three of San Francisco's five starting offensive linemen — left tackle Joe Staley, center Weston Richburg and right tackle Mike McGlinchey — suffered knee injuries during Sunday's loss to the Los Angeles Chargers that leave them questionable for this weekend's game against the Arizona Cardinals.The 49ers are also dealing with injuries to their receivers and defensive backfield, and that's making it difficult for coach Kyle Shanahan and the front office to figure out how to adjust the roster.For example, with quarterback Jimmy Garoppolo having been lost in Week 3 to a torn ACL, the 49ers would like to sign a free agent to provide insurance behind current starter C.J. Beathard and backup Nick Mullens.But with the availability of so many players unknown right now, Shanahan said the team has to stay flexible to see which positions might need reinforcement."We've got a bunch of situations we're looking into," Shanahan said. "Right now, I'd love to answer the quarterback situation because you do want a third one in the building. But there a lot of things that are taking precedent right now."Rookie receiver Dante Pettis, San Francisco's main punt returner, injured his left knee against the Chargers and has been ruled out for this Sunday. Fellow receiver Marquise Goodwin, who starts opposite Pierre Garcon, is questionable with quadriceps and hamstring issues.A bit of good news: Strong safety Jaquiski Tartt, who has missed the past two games with a shoulder injury, is expected back against Arizona. But the status of free safety Adrian Colbert, hampered by a hip contusion, remains unknown.The 49ers also are missing their leader in the secondary, veteran cornerback Richard Sherman, who is likely to miss his second game in a row with a strained left calf.But the most pressing concern has to be the offensive line.The 34-year-old Staley, a five-time Pro Bowler, left Sunday's game in the second quarter and didn't return. He was replaced by Garry Gilliam.Richburg and McGlinchey both returned to the game, eventually, after getting hurt, but they're still hobbled.Keeping Beathard healthy is a priority considering the 49ers have already lost Garoppolo. In his first start of the season Sunday, Beathard generally completed 23 of 37 passes for 298 yards Los Angeles Chargers T-Shirt , two touchdowns and two interceptions.But the second-year quarterback took several big hits from the Chargers' defense, some of them plays on which he could have unloaded the ball or slid in the open field to avoid contact."We want him to stay healthy and we're gonna do everything we can to coach him to do that," Shanahan said. "I know C.J.'s gonna work at it too. There's times he's gotta get down and give up on a play."But it's gonna be hard for me to go too hard on him when it's third-and-5 and the game's on the line. Most quarterbacks are going to attempt (to gain yards) in that situation." Nose tackle Shelby Harris picked off Ben Roethlisberger's 2-yard pass to Antonio Brown in the end zone with 1:03 remaining to seal Denver's 24-17 win over Pittsburgh that snapped the Steelers' six-game winning streak Sunday.The Broncos (5-6) used four takeaways to counter a 97-yard touchdown toss from Roethlisberger to JuJu Smith-Schuster.Roethlisberger was 41 of 56 for 462 yards, but he was intercepted twice and the Steelers (7-3-1) lost two fumbles in losing for the first time since September.Phillip Lindsay rushed for 110 yards and the game-deciding touchdown on just 14 carries for Denver, which also ended the Chargers' six-game winning streak last week and would have snapped Houston's five-game roll were it not for a missed field goal as time expired.CHARGERS 45, CARDINALS 10CARSON, Calif. (AP) 鈥?Philip Rivers tied the NFL record for consecutive completions and set marks for the most to start a game and the highest percentage in a game and Los Angeles rolled over Arizona.The 15-year veteran completed his first 25 passes and was 28 of 29 for 259 yards and three touchdowns in three quarters. It was also his 11th straight game with multiple TD passes.Rivers completed 25 straight passes in the first 2陆 quarters, tying Ryan Tannehill's mark from 2015. The Dolphins QB completed his last seven passes against the Tennessee Titans in on Oct. 18, 2015, and then his first 18 the following week against the Houston Texans.Rivers tied the mark with a 4-yard touchdown pass to Keenan Allen midway through the third quarter. He had his only incompletion on the next possession when he was rushed and was unable to connect on a short pass to Austin Ekeler.Rivers did break Mark Brunell's record for most completions to start a game. Brunell had 22 straight for the Washington Redskins against the Houston Texans on Sept. 24, 2006. Rivers' 96.8 percent accuracy surpassed Kurt Warner's 92.3 percent, which was set in 2009 when he went 24 of 26 for Arizona against Jacksonville.The Cardinals (2-9) jumped out to a 10-0 lead with scores on their first two possessions before the Chargers (8-3) scored touchdowns on six of seven possessions.COLTS 27, DOLPHINS 24INDIANAPOLIS (AP) 鈥?Andrew Luck threw three touchdown passes, Adam Vinatieri kicked a 32-yard field goal as time expired and Indianapolis beat Miami for its fifth consecutive victory.Indianapolis (6-5) scored 13 points in the final 8陆 minutes to erase a 10-point deficit. It's the longest win streak for the Colts since 2014.Miami (5-6) has lost 10 of its past 11 on the road, perhaps none more frustrating than this one. The Dolphins picked off Luck twice, recovered a fumble and partially blocked a punt on their way to a 24-14 lead.It still wasn't enough to derail the resurgent Luck, who was 30 of 37 for 343 yards. He also had the first catch of his NFL career, a 4-yard reception on fourth-and-1 late in the first half. Luck capped that drive with a 1-yard TD pass to Jack Doyle.SEAHAWKS 30, PANTHERS 27CHARLOTTE, N.C. (AP) 鈥?Russell Wilson threw for 339 yards and two touchdowns and Sebastian Janikowski kicked a 31-yard field goal as time expired to lift Seattle to a come-from-behind victory over Carolina.After Graham Gano missed a 52-yard field goal with 1:40 left in the game that would have given the Panthers the lead, Wilson moved around in the pocket until finding Tyler Lockett downfield for a 43-yard completion, setting up the winning kick.The victory puts Seattle (6-5) firmly in the hunt for a wild-card spot in the NFC, while the Panthers (6-5) are reeling after losing three straight and having their 10-game home winning streak snapped.Lockett finished with five catches for 107 yards and a touchdown, while David Moore had four receptions for 103 yards and a score.The Panthers spoiled a record-setting performance from Christian McCaffrey Los Angeles Chargers Hats , who had a franchise-record 237 yards from scrimmage. He had 17 carries for 125 yards and 11 catches for 112 yards, becoming the first Carolina player to surpass 100 yards in both receiving and rushing in the same game.Cam Newton finished 25 of 30 for 256 yards with two touchdown passes and one interception in the end zone. He ran for 63 yards on eight carries.VIKINGS 24, PACKERS 17MINNEAPOLIS (AP) 鈥?Kirk Cousins bounced back from his worst game for Minnesota with 342 passing yards and three touchdowns without a turnover, and the Vikings overcame some early gaffes to outlast depleted Green Bay.Completing 29 of his 38 attempts, Cousins found Dalvin Cook, Stefon Diggs and Adam Thielen for scores. Sheldon Richardson had two sacks to lead the defense's game-long stifling of Aaron Rodgers, and the Vikings (6-4-1) pushed the Packers (4-6-1) further back in the NFC wild-card race.Rodgers threw a touchdown pass to Davante Adams and Aaron Jones scored on a short run for a 14-7 lead early in the second quarter, but the Packers fell to 0-6 on the road and 1-5-1 against the Vikings in their last seven meetings.BROWNS 35, BENGALS 20CINCINNATI (AP) 鈥?Baker Mayfield threw a career-high four touchdown passes in another growing-up-fast performance, and Cleveland ended one of the NFL's longest streaks of road futility with a victory over Cincinnati, which lost quarterback Andy Dalton to a thumb injury.Cleveland (4-6-1) got its first road win since 2015, emphatically snapping a streak of 25 straight road losses that was one shy of the Lions' NFL record. The Browns also ended a run of seven straight losses to their intrastate rival.And just as a Browns safety predicted, it wasn't even close.The Browns surged ahead 28-0 as former head coach Hue Jackson watched helplessly from the opposite sideline. Jackson couldn't win with the Browns 鈥?only three wins in two-plus seasons. Nor could he couldn't beat them as a special defensive assistant with the Bengals (5-6), who lost for the fifth time in six games.EAGLES 25, GIANTS 22PHILADELPHIA (AP) 鈥?Jake Elliott kicked a 43-yard field goal with 22 seconds remaining, and Philadelphia rallied for a victory over New York.The defending Super Bowl champions trailed 12-0 early and were down 19-14 in the fourth quarter before Carson Wentz made key throws and undrafted rookie Josh Adams delivered big runs.Adams scored on a 1-yard touchdown run and ran up the middle for the 2-point conversion to put Philadelphia ahead 22-19.After the Giants tied it on Aldrick Rosas' third field goal, a 29-yarder, the Eagles controlled the ball for 5:27.Coach Doug Pederson went for a fourth-and-1 at the Giants 42 and Wentz completed a 12-yard pass to Nelson Agholor right before the two-minute warning. Adams ran three times and Elliott made the go-ahead kick.The Giants started at their 34 with 16 seconds left but couldn't do much.The Eagles (5-6) stayed in the mix in a mediocre NFC East. The Cowboys and Redskins are tied for first place at 6-5. The Giants fell to 3-8.PATRIOTS 27, JETS 13EAST RUTHERFORD, N.J. (AP) 鈥?Tom Brady threw two touchdown passes and became the NFL's career leader in total yards passing in regular-season and playoff games, leading New England over New York.Brady also reached 3,000 yards passing for the 16th season, tying Peyton Manning for second in NFL history behind Brett Favre's 18. The New England quarterback surpassed the mark early in the fourth quarter with a 17-yard completion to a diving Josh Gordon.Brady has 79,416 yards after going 20 of 31 for 283 yards in the victory that clinched the Patriots (8-3) their 18th straight season with a .500 record or better. That ranks second in NFL history to only Dallas Los Angeles Chargers Womens Hoodie , which had 21 in a row from 1965-85.Brady had just one TD throw in his previous three games, but connected with Rob Gronkowski and Julian Edelman against the AFC East-rival Jets (3-8). Rookie Sony Michel ran for a season-best 133 yards and a TD, and the Patriots had 216 yards rushing to improve to 3-3 on the road this season.RAVENS 34, RAIDERS 17BALTIMORE (AP) 鈥?Rookie quarterback Lamar Jackson ran for a touchdown and threw for a score, Terrell Suggs returned a fumble 43 yards for a TD and Baltimore ran past Oakland.Cyrus Jones took a punt 70 yards for a touchdown to help the Ravens (6-5) win a second straight game for the first time since September.Gus Edwards rushed for 118 yards as part of an effective ground game that enabled Jackson to pass just enough to keep the Raiders (2-9) off guard 鈥?and off the field. Baltimore expanded a three-point halftime lead to 27-17 with two run-heavy touchdown drives that consumed a total of nearly 16 minutes.With starter Joe Flacco out for a second straight game with an injured right hip, Jackson cut down on his rushing attempts, threw more often and got the same result 鈥?a victory. After carrying 27 times for 117 yards last week in his NFL starting debut, Jackson ran 11 times for 71 yards and went 14 for 25 for 178 yards and two interceptions.Suggs clinched it with 5:55 left, lumbering down the right sideline after Oakland's Derek Carr was sacked by Matthew Judon and lost the ball on a fourth-down play.BILLS 24, JAGUARS 21ORCHARD PARK, N.Y. (AP) 鈥?Josh Allen scored the go-ahead touchdown on a 14-yard run in the fourth quarter, and the Bills beat the Jaguars in a game marred by a fight that led to the ejections of Jacksonville running back Leonard Fournette and Buffalo defensive end Shaq Lawson.Fournette scored twice to tie it at 14 in the second quarter. He finished with 95 yards on 18 carries before he was thrown out with 2:57 left in the third.Allen also threw a 75-yard touchdown pass to Robert Foster in the rookie quarterback's first game since missing four with a sprained throwing elbow. Rookie receiver Isaiah McKenzie scored on a 6-yard run off a sweep, and Buffalo (4-7) came off its bye week off to win consecutive games for the first time this season.The Jaguars (3-8) dropped their seventh consecutive game in their longest losing streak since a nine-game slide in 2016, which led directly to Gus Bradley being fired and replaced by current coach Doug Marrone.BUCCANEERS 27, 49ERS 9TAMPA, Fla. (AP) 鈥?Jameis Winston threw for 312 yards and two touchdowns to help Tampa Bay snap a four-game losing streak.Winston, benched last month after turning the ball over 11 times in 14 quarters, completed 29 of 38 passes without an interception.The fourth-year pro, who's shared the starting job with Ryan Fitzpatrick, tossed scoring passes of 6 yards to Cameron Brate and 28 yards to Adam Humphries on a play he extended by scrambling to his right before throwing back toward the center of the field.Tampa Bay (4-7), meanwhile, had four sacks and forced a turnover on defense for the first time in eight games, with Ryan Smith and Isaiah Johnson coming up with the team's first interceptions since a loss to Pittsburgh on Sept. 24.Matt Breida rushed for 106 yards for the 49ers (2-9). Custom Denver Broncos Jerseys